中枢神経グループ

研究メンバー

教員

伏見育崇（代表、准教授）
中島諭　（助教）
奥知左智（特定助教）
坂田昭彦（助教）
山本貴之（特定病院助教）
大谷紗代（特定助教）

大学院生

櫻間梓　　(4)
池田賢司　(4)
伊藤秀一　(3)
梅花優貴　(2)
馬　永萍　(2)
諸岡紳　 (1)

研究テーマ

中枢神経画像診断グループ（ニューログループ）の構成メンバーは、2023年4月現在で教員6名、大学院生6名、客員研究員3名で活動しています。一昨年までは海外からの留学生も在籍されていました。
私たちは、患者さん、関係診療科、放射線部の皆様に多大なご協力をいただき、CT、MR、RI (PET, SPECT, PET/MRI) を含めたモダリティを活用しながら、画像診断の診療・研究を行っています。
また、関係各社のご協力のもと、最新技術を用いた産学共同研究なども行っています！
大学院の先生には、個人に合わせた放射線診断医のサブスペシャリティ形成をしていただく機会を提供し、学位取得へ向け頑張っていただきます。ニューロが苦手だけど勉強をしたい人も大歓迎です。

留学について

昨年度までは大学院卒業後１名の先生がアメリカ・カルフォルニア大学ロサンゼルス校に留学されていました。
留学は大変な面も多いですが、貴重な人生経験となりますので、若い先生にはぜひ留学にチャレンジしていただきたいです。
なお、過去の留学先としては、フランス・ボルドー大学、アメリカ・ジョンズホプキンス大学、アメリカ・ユタ大学、イギリス・ユニバーシティ・カレッジ・ロンドン大学などがあります。

業績

2024年

Ikeda S, Sakata A*, Arakawa Y, Mineharu Y, Makino Y, Takeuchi Y, Fushimi Y, Okuchi S, Nakajima S, Otani S, Nakamoto Y. Clinical and imaging characteristics of supratentorial slioma with IDH2 mutation. Neuroradiology. 2024 Apr 24. https://doi.org/10.1007/s00234-024-03361-8.
Ito S, Okuchi S*, Fushimi Y, Otani S, Wicaksono KP, Sakata A, Miyake KK, Numamoto H, Nakajima S, Tagawa H, Tanji M, Sano N, Kondo H, Imai R, Saga T, Fujimoto K, Arakawa Y, Nakamoto Y. Thin-slice reverse encoding distortion correction DWI facilitates visualization of non-functioning pituitary neuroendocrine tumor (PitNET)/pituitary adenoma and surrounding normal structures. Eur Radiol Exp. 2024 Mar 7;8(1):28. https://doi.org/10.1186/s41747-024-00430-8.

2023年

Tagawa H, Fushimi Y*, Funaki T, Nakajima S, Sakata A, Okuchi S, Hinoda T, Grinstead J, Ahn S, Hidaka Y, Yoshida K, Miyamoto S, Nakamoto Y. Vessel wall MRI in moyamoya disease: arterial wall enhancement varies depending on age, arteries, and disease progression. Eur Radiol 2023. https://doi.org/10.1007/s00330-023-10251-9.
Takiya M, Fushimi Y*, Sakamoto M, Yoshida T, Ueno K, Nakajima S, Sakata A, Okuchi S, Otani S, Tagawa H, Morimoto N, Nakamoto Y. Incidence of neurocutaneous melanosis in Japanese pediatric patients with congenital melanocytic nevi. Sci Rep. 2023. https://doi.org/10.1038/s41598-023-43829-w.
Fushimi Y*, Nakajima S, Sakata A, Okuchi S, Otani S, Nakamoto Y. Value of Quantitative Susceptibility Mapping in Clinical Neuroradiology. J Magn Reson Imaging. 2023 Sep 8. https://doi.org/10.1002/jmri.29010.
Oshima S, Fushimi Y*, Miyake KK, Nakajima S, Sakata A, Okuchi S, Hinoda T, Otani S, Numamoto H, Fujimoto K, Shima A, Nambu M, Sawamoto N, Takahashi R, Ueno K, Saga T, Nakamoto Y. Denoising approach with deep learning-based reconstruction for neuromelanin-sensitive MRI: image quality and diagnostic performance. Jpn J Radiol. 2023 Nov;41(11):1216-1225. https://doi.org/10.1007/s11604-023-01452-9.
Wang Y, Fushimi Y*, Arakawa Y, Shimizu Y, Sano K, Sakata A, Nakajima S, Okuchi S, Hinoda T, Oshima S, Otani S, Ishimori T, Tanji M, Mineharu Y, Yoshida K, Nakamoto Y. Evaluation of isocitrate dehydrogenase mutation in 2021 world health organization classification grade 3 and 4 glioma adult-type diffuse gliomas with 18F-fluoromisonidazole PET. Jpn J Radiol. 2023 Nov;41(11):1255-1264. https://doi.org/10.1007/s11604-023-01450-x.
Yasutaka Fushimi, Satoshi Nakajima. Can we distinguish atypical primary brain lymphoma from glioblastoma multiforme by looking at the non-enhancing tumor? Eur Radiol. 2023 Aug;33(8):5355-5356. https://doi.org/10.1007/s00330-023-09750-6.
Yasutaka Fushimi, Toshiaki Taoka, Shinji Naganawa. From pituitary adenoma to PitNET: it is time to discuss PitNET/pituitary adenoma. Jpn J Radiol. 2023 Aug;41(8):787-788. https://doi.org/10.1007/s11604-023-01412-3

2022年

Satoshi Nakajima, Yasutaka Fushimi*, Takuya Hinoda, Akihiko Sakata, Sachi Okuchi, Yoshiki Arakawa, Takayoshi Ishimori, Yuji Nakamoto. Brain imaging of sequential acquisition using a flexible PET scanner and 3-T MRI: quantitative and qualitative assessment. Annals of Nuclear Medicine 2023 Apr;37(4):209-218. https://doi.org/10.1007/s12149-022-01817-6/
Satoshi Ikeda, Akihiko Sakata*, Yasutaka Fushimi, Sachi Okuchi, Yoshiki Arakawa, Yasuhide Makino, Yohei Mineharu, Satoshi Nakajima, Takuya Hinoda, Kazumichi Yoshida, Susumu Miyamoto, Yuji Nakamoto. Telomerase reverse transcriptase promoter mutation and histologic grade in IDH wild-type histological lower-grade gliomas: the value of perfusion-weighted image, diffusion-weighted image, and 18F-FDG-PET. European Journal of Radiology 2023. https://doi.org/10.1016/j.ejrad.2022.110658/
Nakamura Y, Fushimi Y*, Hinoda T, Nakajima S, Sakata A, Okuchi S, Otani S, Tagawa H, Wang Y, Ikeda S, Kawashima H, Uemura MT, Nakamoto Y. Hemosiderin Detection inside the Mammillary Bodies Using Quantitative Susceptibility Mapping on Patients with Wernicke-Korsakoff Syndrome. Magn Reson Med Sci. 2022. https://doi.org/10.2463/mrms.ici.2022-0109/
Krishna Pandu Wicaksono, Yasutaka Fushimi*, Satoshi Nakajima, Akihiko Sakata, Sachi Okuchi, Takuya Hinoda, Sonoko Oshima, Sayo Otani, Hiroshi Tagawa, Yuta Urushibata, Yuji Nakamoto. Accuracy, repeatability, and reproducibility of T1 and T2 relaxation times measurement by 3D magnetic resonance fingerprinting with different dictionary resolutions. European Radiology 2023 Apr;33(4):2895-2904. https://doi.org/10.1007/s00330-022-09244-x/
Sayo Otani, Yasutaka Fushimi*, Kogoro Iwanaga, Seiichi Tomotaki, Taiki Shimotsuma, Satoshi Nakajima, Akihiko Sakata, Sachi Okuchi, Takuya Hinoda, Krishna Pandu Wicaksono, Junko Takita, Masahiko Kawai, Yuji Nakamoto. Evaluation of deep gray matter for early brain development using quantitative susceptibility mapping. European Radiology 2023. https://doi.org/10.1007/s00330-022-09267-4/
Sachi Okuchi, Yasutaka Fushimi*, Kazumichi Yoshida, Satoshi Nakajima, Akihiko Sakata, Takuya Hinoda, Sayo Otani, Hajime Sagawa, Kun Zhou, Yukihiro Yamao, Masakazu Okawa, Yuji Nakamoto. Comparison of TGSE-BLADE DWI, RESOLVE DWI, and SS-EPI DWI in healthy volunteers and patients after cerebral aneurysm clipping. Scientific Reports 2022. https://doi.org/10.1038/s41598-022-22760-6/
Wicaksono KP, Fujimoto K*, Fushimi Y, Sakata A, Okuchi S, Hinoda T, Nakajima S, Yamao Y, Yoshida K, Miyake KK, Numamoto H, Saga T, Nakamoto Y. Super-resolution application of generative adversarial network on brain time-of-flight MR angiography: image quality and diagnostic utility evaluation. European Radiology 2023 Feb;33(2): 33:936–946. https://doi.org/10.1007/s00330-022-09103-9/
Yasutaka Fushimi*, Kazumichi Yoshida, Masakazu Okawa, Takakuni Maki, Satoshi Nakajima, Akihiko Sakata, Sachi Okuchi, Takuya Hinoda, Mitsunori Kanagaki, Yuji Nakamoto. Vessel wall MR imaging in neuroradiology. Radiol Med. 2022 Sep;127(9):1032-1045. https://doi.org/10.1007/s11547-022-01528-y/
Akihiko Sakata*, Yasutaka Fushimi, Yoshiki Arakawa, Yoichi Shimizu, Yuji Nakamoto. 18F-FMISO PET of an Intracranial Tuberculoma: A Great Mimicker. Clinical Nuclear Medicine 2022. https://doi.org/10.1097/rlu.0000000000004471/
Yasuhiro Fukushima, Yasutaka Fushimi*, Takeshi Funaki, Akihiko Sakata, Takuya Hinoda, Satoshi Nakajima, Ryo Sakamoto, Kazumichi Yoshida, Susumu Miyamoto, Yuji Nakamoto. Evaluation of moyamoya disease in CT angiography using ultra-high-resolution computed tomography: application of deep learning reconstruction. European Journal of Radiology 2022. https://doi.org/10.1016/j.ejrad.2022.110294/
Sakata A, Sakamoto R, Fushimi Y*, Nakajima S, Hinoda T, Oshima S, Wetzl J, Schmidt M, Okawa M, Yoshida K, Miyamoto S, Nakamoto Y. Low-dose contrast-enhanced time-resolved angiography with stochastic trajectories with iterative reconstruction (IT-TWIST-MRA) in brain arteriovenous shunt. Eur Radiol. 2022 Aug;32(8):5392-5401. https://doi.org/10.1007/s00330-022-08678-7/

2021年

Sakurama A, Fushimi Y*, Nakajima S, Sakata A, Hinoda T, Oshima S, Otani S, Wicaksono KP, Liu W, Maki T, Okada T, Takahashi R, Nakamoto Y. Clinical Application of MPRAGE Wave Controlled Aliasing in Parallel Imaging (Wave-CAIPI): A Comparative Study with MPRAGE GRAPPA. Magn Reson Med Sci. 2021. https://doi.org/10.2463/mrms.mp.2021-0065/
Nakajima S, Fushimi Y*, Funaki T, Okubo G, Sakata A, Hinoda T, Yokota Y, Oshima S, Otani S, Kikuchi T, Okada T, Yoshida K, Miyamoto S, Nakamoto Y. Quiet Diffusion-weighted MR Imaging of the Brain for Pediatric Patients with Moyamoya Disease. Magn Reson Med Sci. 2021. https://doi.org/10.2463/mrms.mp.2020-0174/
Mizue Suzuki, Yasutaka Fushimi*, Tomohisa Okada, Takuya Hinoda, Ryusuke Nakamoto, Yoshiki Arakawa, Nobukatsu Sawamoto, Kaori Togashi & Yuji Nakamoto. Quantitative and qualitative evaluation of sequential PET/MRI using a newly developed mobile PET system for brain imaging. Japanese Journal of Radiology 2021 Jul;39(7):669-680. https://doi.org/10.1007/s11604-021-01105-9/

2020年

Sonoko Oshima, Yasutaka Fushimi*, Tomohisa Okada, Satoshi Nakajima, Yusuke Yokota, Atsushi Shima, John Grinstead, Sinyeob Ahn, Nobukatsu Sawamoto, Ryosuke Takahashi, Yuji Nakamoto. Neuromelanin-Sensitive Magnetic Resonance Imaging Using DANTE Pulse. Mov Disord. 2021 Apr;36(4):874-882. https://doi.org/10.1002/mds.28417/
Akihiko Sakata, Yasutaka Fushimi*, Tomohisa Okada, Satoshi Nakajima, Takuya Hinoda, Peter Speier, Michaela Schmidt, Christoph Forman, Kazumichi Yoshida, Hiroharu Kataoka, Susumu Miyamoto, Yuji Nakamoto. Evaluation of Cerebral Arteriovenous Shunts: A Comparison of Parallel Imaging Time-of-Flight Magnetic Resonance Angiography (TOF-MRA) and Compressed Sensing TOF-MRA to Digital Subtraction Angiography. Neuroradiology 2021 Jun;63(6):879-887. https://doi.org/10.1007/s00234-020-02581-y/
Nakajima S*, Fushimi Y, Kawashima H, Murai T, Nakamoto Y. Cerebral Infarction with Increased Uptake on 123I-FP-CIT SPECT. Clin Nucl Med. 2020 Nov 10. https://doi.org/10.1097/rlu.0000000000003366/
Sayo Otani, Yasutaka Fushimi*, Kogoro Iwanaga, Seiichi Tomotaki, Yusuke Yokota, Sonoko Oshima, Azusa Sakurama, Krishna Pandu Wicaksono, Takuya Hinoda, Akihiko Sakata, Satoshi Nakajima, Tomohisa Okada, Junko Takita, Masahiko Kawai, Kaori Togashi. Signal Intensity and Volume of Pituitary and Thyroid Glands in Preterm and Term Infants. J Magn Reson Imaging. 2021 Apr;53(4):1151-1161. https://doi.org/10.1002/jmri.27395/
Hajime Sagawa, Yasutaka Fushimi*, Satoshi Nakajima, Koji Fujimoto, Kanae Kawai Miyake, Hitomi Numamoto, Koji Koizumi, Masahito Nambu, Hiroharu Kataoka, Yuji Nakamoto, Tsuneo Saga. Deep Learning-based Noise Reduction for Fast Volume Diffusion Tensor Imaging: Assessing the Noise Reduction Effect and Reliability of Diffusion Metrics. Magn Reson Med Sci. 2021 Dec 1;20(4):450-456. https://doi.org/10.2463/mrms.tn.2020-0061/
Krishna Pandu Wicaksono, Yasutaka Fushimi*, Satoshi Nakajima, Yusuke Yokota, Sonoko Oshima, Sayo Otani, Azusa Sakurama, Atsushi Shima, Nobukatsu Sawamoto, Tomohisa Okada, and Yuji Nakamoto. Two-Minute Quantitative Susceptibility Mapping From Three-Dimensional Echo-Planar Imaging. Accuracy, Reliability, and Detection Performance in Patients With Cerebral Microbleeds. Investigative Radiology: 56 (2): 69-77. https://doi.org/10.1097/rli.0000000000000708/
Yokota Y, Okada T*, Fushimi Y, Yamamoto A, Nakajima S, Fujimoto K, Oshima S, Koerzdoerfer G, Nittka M, Pfeuffer J, Togashi K. Acceleration of 2D-MR fingerprinting by reducing the number of echoes with increased in-plane resolution: a volunteer study. MAGMA. 2020 Dec;33(6):783-791. https://doi.org/10.1007/s10334-020-00842-8/
Sonoko Oshima, Yasutaka Fushimi*, Tomohisa Okada, Kyoko Takakura, Chunlei Liu, Yusuke Yokota, Yoshiki Arakawa, Nobukatsu Sawamoto, Susumu Miyamoto, Kaori Togashi. Brain MRI with Quantitative Susceptibility Mapping: Relationship to CT Attenuation Values. Radiology. 2020 Mar;294(3):600-609. https://doi.org/10.1148/radiol.2019182934/

諸先輩の築かれた素晴らしい環境を活かし、関係される皆様の期待に応えるべく、中枢神経系画像診断を通じて頑張っていきたいと存じます。